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Article

Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth.

The American journal of pathology - 1 Sept 2007

O'Neill Christine F, Urs Sumithra, Cinelli Christina, Lincoln Alexis, Nadeau Robert J, León Ruth, Toher Jessica, Mouta-Bellum Carla, Friesel Robert E, Liaw Lucy

Abstract excerpt

Notch functions as an oncogene or tumor inhibitor in various cancers, and decreases in Notch2 expression are associated with increasing grade of human breast cancer. We constitutively activated Notch signaling with intracellular domain (ICD) expression in the human adenocarcinoma line MDA-MB-231....

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Identifiers

PMID: 17675579
DOI: 10.2353/ajpath.2007.061029
PMCID: PMC1959488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17675579-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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