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Induction of Cyclin D1 Transcription and CDK2 Activity by Notch <sup>ic</sup> : Implication for Cell Cycle Disruption in Transformation by Notch <sup>ic</sup>

1 Sept 2001

Abstract excerpt

Notch genes encode a family of transmembrane proteins that are involved in many cellular processes such as differentiation, proliferation, and apoptosis. Although it is well established that all four Notch genes can act as oncogenes, the mechanism by which Notch proteins transform cells remains unknown. Previously, we have shown that transformation of RKE cells can be conditionally induced by hormone activation...

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PMID: 11486031
DOI: 10.1128/mcb.21.17.5925-5934.2001

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Induction of Cyclin D1 Transcription and CDK2 Activity by Notch <sup>ic</sup> : Implication for Cell Cycle Disruption in Transformation by Notch <sup>ic</sup>PMID 11486031Read ↗

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