Article
South African mutations of the CCR5 coreceptor for HIV modify interaction with chemokines and HIV Envelope protein.
Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2010
Folefoc Asongna T, Fromme Bernhard J, Katz Arieh A, Flanagan Colleen A
Abstract excerpt
The CCR5 chemokine receptor is the major coreceptor for HIV-1 and the receptor for CC-chemokines, MIP-1alpha, MIP-1beta, and regulated upon activation normal T-cell-expressed and secreted. Individuals, who are homozygous for the nonfunctional CCR5Delta32 allele, are largely resistant to HIV-1 infection. Four unique mutations that affect the amino acid sequence of CCR5 have been identified in South Africa. We have...
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