Article
Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2010
Sun Z, Chen J, Aakre J, Marks R S, Garces Y Y, Jiang R, Idowu O, Cunningham J M, Liu Y, Pankratz V S, Yang P
Abstract excerpt
BACKGROUND: Small-cell lung cancer (SCLC) carries the worst prognosis among lung cancer diagnoses. Combined radiation and chemotherapy is the standard of care; however, treatment outcomes vary. Variability in the rate at which chemotherapy agents are metabolized and in the capacity of repairing DNA damage has been hypothesized to be partly responsible for the treatment response variation. Genes in the glutathione...
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