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Article

Systematic evaluation of genetic variants in three biological pathways on patient survival in low-stage non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2011

Pankratz V Shane, Sun Zhifu, Aakre Jeremiah, Li Yan, Johnson Cassandra, Garces Yolanda I, Aubry Marie C, Molina Julian R, Wigle Dennis A, Yang Ping

Abstract excerpt

INTRODUCTION: Studies from selected candidate genes suggest that single-nucleotide polymorphisms (SNPs) involved in glutathione metabolism, DNA repair, or inflammatory responses may affect overall survival (OS) in stages I to II or low-stage non-small cell lung cancer (LS-NSCLC); however, results are inconclusive. In this study, we took a systematic pathway-based approach to simultaneously evaluate the impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21792076
DOI: 10.1097/JTO.0b013e318223bf05
PMCID: PMC3158278

Genes

ABCC4
GSTM5
GSTA2
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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