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Genome-wide examination of genetic variants associated with response to platinum-based chemotherapy in patients with small-cell lung cancer.

Pharmacogenetics and genomics - 1 Jun 2010

Wu Chen, Xu Binghe, Yuan Peng, Ott Jurg, Guan Yin, Liu Yu, Liu Zhe, Shen Yuanyuan, Yu Dianke, Lin Dongxin

Abstract excerpt

OBJECTIVES: Small-cell lung cancer (SCLC) accounts for about 20% of total lung cancer, and systemic chemotherapy is the major therapy for all stages of SCLC. Although most SCLC patients are characterized by initial chemosensitivity to the standard first-line platinum-based regimens, a significant fraction of patients are intrinsic nonresponders. METHODS: Genome-wide scan of 440 093 single-nucleotide polymorphisms...

Topics

Carboplatin
Cisplatin
Etoposide
Female
Genes
Genome
Humans
Inuit
Lung Neoplasms
Male
Middle Aged
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platinum

Polymorphism, Single Nucleotide

R-SNARE Proteins

Small Cell Lung Carcinoma

Source

Identifiers

PMID: 20463552
DOI: 10.1097/FPC.0b013e32833a6890

Genes

BCR
BTBD3
STXBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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