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Article

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila.

The EMBO journal - 2 Jun 2010

Büssing Ingo, Yang Jr-Shiuan, Lai Eric C, Grosshans Helge

Abstract excerpt

MicroRNA (miRNA) biogenesis proceeds from a primary transcript (pri-miRNA) through the pre-miRNA into the mature miRNA. Here, we identify a role of the Caenorhabditis elegans nuclear export receptor XPO-1 and the cap-binding proteins CBP-20/NCBP-2 and CBP-80/NCBP-1 in this process. The RNA-mediated interference of any of these genes causes retarded heterochronic phenotypes similar to those observed for animals...

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Source

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Identifiers

PMID: 20436454
DOI: 10.1038/emboj.2010.82
PMCID: PMC2885935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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