A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.

doi:10.1097/FPC.0b013e32833a6d4a

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Article

A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity.

Pharmacogenetics and genomics - 1 Jun 2010

Arsenault Jason, Lehoux Julie, Lanthier Luc, Cabana Jérôme, Guillemette Gaëtan, Lavigne Pierre, Leduc Richard, Escher Emanuel

Abstract excerpt

BACKGROUND AND OBJECTIVE: AT1 is the principal receptor for angiotensin II (AngII), which regulates blood pressure and osmotic homeostasis. Earlier studies have shown that position 163 interacts with the antihypertensive nonpeptide antagonist, Losartan. A recently discovered polymorphism found in humans (rs12721226) coding for residue 163 led us to determine whether this polymorphism would affect Losartan...

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PMID: 20436376
DOI: 10.1097/FPC.0b013e32833a6d4a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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