Article
Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
The Journal of biological chemistry - 9 Jul 2010
Chinnakkannu Panneerselvam, Samanna Venkatesababa, Cheng Guangmao, Ablonczy Zsolt, Baicu Catalin F, Bethard Jennifer R, Menick Donald R, Kuppuswamy Dhandapani, Cooper George
Abstract excerpt
In severe pressure overload-induced cardiac hypertrophy, a dense, stabilized microtubule network forms that interferes with cardiocyte contraction and microtubule-based transport. This is associated with persistent transcriptional up-regulation of cardiac alpha- and beta-tubulin and microtubule-s...
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