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The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction

14 Dec 2023

Abstract excerpt

BACKGROUND: Brugada syndrome is associated with loss-of-function SCN5A variants, yet these account for only ≈20% of cases. A recent genome-wide association study identified a novel locus within MAPRE2 , which encodes EB2 (microtubule end-binding protein 2), implicating microtubule involvement in Brugada syndrome. METHODS: A mapre2 knockout zebrafish model was generated using CRISPR/Cas9 (clustered regularly...

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PMID: 38095085
DOI: 10.1161/circresaha.123.323231

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