Article
Evidence for an allosteric mechanism of substrate release from membrane-transporter accessory binding proteins.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011
Marinelli Fabrizio, Kuhlmann Sonja I, Grell Ernst, Kunte Hans-Jörg, Ziegler Christine, Faraldo-Gómez José D
Abstract excerpt
Numerous membrane importers rely on accessory water-soluble proteins to capture their substrates. These substrate-binding proteins (SBP) have a strong affinity for their ligands; yet, substrate release onto the low-affinity membrane transporter must occur for uptake to proceed. It is generally accepted that release is facilitated by the association of SBP and transporter, upon which the SBP adopts a conformation...
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