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Article

Structural Insights into of the Allosteric Activation of the LicT Antiterminator by PTS-Mediated Phosphorylation.

Structure (London, England : 1993) - 4 Feb 2020

Yang Yinshan, Padilla André, de Guillen Karine, Mammri Léa, Gracy Jérome, Declerck Nathalie, Déméné Hélène

Abstract excerpt

LicT belongs to an essential family of bacterial transcriptional antitermination proteins controlling the expression of sugar-metabolizing operons. When activated, they bind to nascent mRNAs, preventing premature arrest of transcription. The RNA binding capacity of the N-terminal domain CAT is controlled by phosphorylations of two homologous regulation modules by the phosphotransferase system (PTS). Previous...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31753618
DOI: 10.1016/j.str.2019.10.017

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