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Article

Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jul 2010

Perreau-Lenz Stéphanie, Sanchis-Segura Carles, Leonardi-Essmann Fernando, Schneider Miriam, Spanagel Rainer

Abstract excerpt

The present study has been designed to assess specifically the involvement of the clock gene mPer2 in morphine-induced tolerance and withdrawal. At first, we checked the absence of initial differences in the expression of several gene transcripts involved in the development of morphine dependence in Per2(Brdm1) mutant mice and in their respective wild-type (WT) control littermates. Morphine-induced tolerance as...

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Identifiers

PMID: 20434889
DOI: 10.1016/j.euroneuro.2010.03.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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