Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in <i>Xenopus</i>

30 Apr 2010

Abstract excerpt

Podocytes are highly specialized cells in the vertebrate kidney. They participate in the formation of the size-exclusion barrier of the glomerulus/glomus and recruit mesangial and endothelial cells to form a mature glomerulus. At least six transcription factors (wt1, foxc2, hey1, tcf21, lmx1b and mafb) are known to be involved in podocyte specification, but how they interact to drive the differentiation program...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Kidney Cyst Diseases
Share to Renal and related cancers
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20431116
DOI: 10.1242/dev.042887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in <i>Xenopus</i>PMID 20431116Read ↗

Transcriptional regulation of podocyte specification and differentiationSemantic proximity Read ↗

MAFB drives differentiation by permitting WT1 binding to podocyte specific promotersSemantic proximity Read ↗

<i>osr1</i> maintains renal progenitors and regulates podocyte development by promoting <i>wnt2ba</i> through antagonism of <i>hand2</i>Semantic proximity Read ↗

Repair Problems in Podocytes: Wnt, Notch, and GlomerulosclerosisSemantic proximity Read ↗

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms’ Tumor 1 Target Genes in Podocyte Differentiation and MaintenanceSemantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.Semantic proximity Read ↗

Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafishSemantic proximity Read ↗

Ectopic Notch Activation in Developing Podocytes Causes GlomerulosclerosisSemantic proximity Read ↗

Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature PodocytesSemantic proximity Read ↗

Requirement of Wnt/beta-catenin signaling in pronephric kidney development.Semantic proximity Read ↗

The signaling pathways of LMX1B and its role in glomerulosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.