Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.

Journal of the American Society of Nephrology : JASN - 1 Dec 2014

He Bing, Ebarasi Lwaki, Zhao Zhe, Guo Jing, Ojala Juha R M, Hultenby Kjell, De Val Sarah, Betsholtz Christer, Tryggvason Karl

Abstract excerpt

Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity. The exclusive expression of NPHS2 in podocytes reflects its unique function and raises interesting questions about its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Forkhead Transcription Factors

Share to LIM-Homeodomain Proteins

Share to Microscopy, Confocal

Share to Podocytes

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24854274
DOI: 10.1681/ASN.2012080823
PMCID: PMC4243338

Genes

NPHS2
CCNC
MEIS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.PMID 24854274Read ↗

Transcriptional regulation of podocyte specification and differentiationSemantic proximity Read ↗

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiationSemantic proximity Read ↗

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiationSemantic proximity Read ↗

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseasesSemantic proximity Read ↗

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms’ Tumor 1 Target Genes in Podocyte Differentiation and MaintenanceSemantic proximity Read ↗

Interaction with Podocin Facilitates Nephrin SignalingSemantic proximity Read ↗

NEPH1 defines a novel family of podocin‐interacting proteinsSemantic proximity Read ↗

WT1 Activates a Glomerular-Specific Enhancer Identified from the Human Nephrin GeneSemantic proximity Read ↗

Two Gene Fragments that Direct Podocyte-Specific Expression in Transgenic MiceSemantic proximity Read ↗

The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.Semantic proximity Read ↗

The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.