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Article

Ectopic Notch Activation in Developing Podocytes Causes Glomerulosclerosis

12 Mar 2008

Abstract excerpt

Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased expression of Notch transcriptional targets in developing podocytes after the determination of cell fate suggests that constitutive Notch signaling may oppose podocyte differentiation. This study determined the effects of constitutive Notch signaling on podocyte differentiation by...

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Identifiers

PMID: 18337488
DOI: 10.1681/asn.2007050596

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