Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.

doi:10.1371/journal.pone.0062376

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Article

Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.

PloS one - 1 Jan 2013

Swaminathan Bhairavi, Cuapio Angélica, Alloza Iraide, Matesanz Fuencisla, Alcina Antonio, García-Barcina Maria, Fedetz Maria, Fernández Oscar, Lucas Miguel, Orpez Teresa, Pinto-Medel M Jesus, Otaegui David, Olascoaga Javier, Urcelay Elena, Ortiz Miguel A, Arroyo Rafael, Oksenberg Jorge R, Antigüedad Alfredo, Tolosa Eva, Vandenbroeck Koen

Abstract excerpt

CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation. In this study, we performed a haptag SNP screen of the CD6 gene locus using a total of thirteen...

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PMID: 23638056
DOI: 10.1371/journal.pone.0062376
PMCID: PMC3634811

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