Article
Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype.
Respiratory research - 29 Apr 2010
Pera Tonio, Gosens Reinoud, Lesterhuis Andries H, Sami Riham, van der Toorn Marco, Zaagsma Johan, Meurs Herman
Abstract excerpt
BACKGROUND: A major feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, which includes an increased airway smooth muscle (ASM) mass. The mechanisms underlying ASM remodelling in COPD are currently unknown. We hypothesized that cigarette smoke (CS) and/or lipopolysaccharide (LPS), a major constituent of CS, organic dust and gram-negative bacteria, that may be involved in recurrent airway...
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