Article
ERK1/2 signaling pathway modulates the airway smooth muscle cell phenotype in the rat model of chronic asthma.
Respiration; international review of thoracic diseases - 1 Jan 2007
Xie Min, Liu Xian-Sheng, Xu Yong-Jian, Zhang Zhen-Xiang, Bai Jing, Ni Wang, Chen Shi-Xin
Abstract excerpt
BACKGROUND: It has been demonstrated that the phenotypic modulation of airway smooth muscle cells (ASMCs) is important to the pathogenesis of airway remodeling in chronic asthma. The extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is one of the most important transduction pathways involved in the process of asthma; however, its role in the phenotypic transition of ASMCs remains unclear....
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