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Article

L-thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2015

Dekkers Bart G J, Naeimi Saeideh, Bos I Sophie T, Menzen Mark H, Halayko Andrew J, Hashjin Goudarz Sadeghi, Meurs Herman

Abstract excerpt

Hypothyroidism may reduce, whereas hyperthyroidism may aggravate, asthma symptoms. The mechanisms underlying this relationship are largely unknown. Since thyroid hormones have central roles in cell growth and differentiation, we hypothesized that airway remodeling, in particular increased airway smooth muscle (ASM) mass, may be involved. To address this hypothesis, we investigated the effects of triiodothyronine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25480330
DOI: 10.1152/ajplung.00071.2014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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