Article
A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival.
Cancer prevention research (Philadelphia, Pa.) - 1 May 2010
Penney Kathryn L, Schumacher Fredrick R, Li Haojie, Kraft Peter, Morris J Steven, Kurth Tobias, Mucci Lorelei A, Hunter David J, Kantoff Philip W, Stampfer Meir J, Ma Jing
Abstract excerpt
The role of selenium in prostate cancer (PCa) risk remains controversial, but many epidemiologic studies suggest an inverse association with more aggressive disease. A recently discovered selenoprotein, SEP15, which is highly expressed in the prostate, may play a role either independently or by modifying the effects of selenium. We genotyped four common single-nucleotide polymorphisms capturing common variation...
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