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Article

Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival.

The Prostate - 1 May 2013

Penney Kathryn L, Li Haojie, Mucci Lorelei A, Loda Massimo, Sesso Howard D, Stampfer Meir J, Ma Jing

Abstract excerpt

BACKGROUND: Low levels of selenium have been associated with increased risk of prostate cancer (PCa). Selenoprotein P is the most abundant selenoprotein in serum and delivers ten selenocysteine residues to tissues. Variation in the selenoprotein P gene (SEPP1) may influence PCa development or modify the effects of selenium. We examined the association of SEPP1 single nucleotide polymorphisms (SNPs) with PCa risk...

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PMID: 23129481
DOI: 10.1002/pros.22611
PMCID: PMC3640488

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