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Article

Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.

Cancer research - 15 Dec 2008

Cooper Matthew L, Adami Hans-Olov, Grönberg Henrik, Wiklund Fredrik, Green Fiona R, Rayman Margaret P

Abstract excerpt

Selenium may affect prostate cancer risk via its plasma carrier selenoprotein P which shows dramatically reduced expression in prostate cancer tumors and cell lines. The selenoprotein P (SEPP1) Ala234 single nucleotide polymorphism (SNP) allele is associated with lower plasma selenoprotein P in men, reducing the concentration/activity of other antioxidant selenoproteins. Selenium status also modifies the effect...

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Identifiers

PMID: 19074884
DOI: 10.1158/0008-5472.CAN-08-1827
PMCID: PMC2800981

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SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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