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Article

Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2016

Chan June M, Darke Amy K, Penney Kathryn L, Tangen Catherine M, Goodman Phyllis J, Lee Gwo-Shu Mary, Sun Tong, Peisch Sam, Tinianow Alex M, Rae James M, Klein Eric A, Thompson Ian M, Kantoff Philip W, Mucci Lorelei A

Abstract excerpt

BACKGROUND: Epidemiologic studies and secondary analyses of randomized trials supported the hypothesis that selenium and vitamin E lower prostate cancer risk. However, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no benefit of either supplement. Genetic variants involved in selenium or vitamin E metabolism or transport may underlie the complex associations of selenium and vitamin E. METHODS:...

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Identifiers

PMID: 27197287
DOI: 10.1158/1055-9965.EPI-16-0104
PMCID: PMC5086806

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CAT
IMPACT
PRDX6
SOD1
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TTPA
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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