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Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia

23 May 2025

Abstract excerpt

Somatic mutations in genes encoding isocitrate dehydrogenase (IDH) enzymes are found in approximately 20% of acute myeloid leukemia (AML) and are more common in patients with advanced age, intermediate risk-AML or NPM1 mutations [ 1 ]. They involve 3 mutational hotspots within the IDH enzymatic active sites, resulting in single amino acid substitutions at codon R132 of IDH1 ( IDH1 R132 ) and codons R140 and R172...

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PMID: 40410134
DOI: 10.1038/s41408-025-01304-x

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