Article
Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array.
Experimental hematology - 1 Aug 2009
Kawamata Norihiko, Ogawa Seishi, Gueller Saskia, Ross Samuel H, Huynh Thien, Chen John, Chang Andrew, Nabavi-Nouis Shayan, Megrabian Nairi, Siebert Reiner, Martinez-Climent Jose A, Koeffler H Phillip
Abstract excerpt
OBJECTIVE: Mantle cell lymphoma (MCL) is a lymphoma characterized by aberrant activation of CCND1/cyclin D1 followed by sequential genetic abnormalities. Genomic abnormalities in MCL have been extensively examined by classical cytogenetics and microarray-based comparative genomic hybridization techniques, pointing out a number of alterations in genomic regions that correlate with the neoplastic phenotype and...
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