Article
Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.
Blood - 26 Mar 2009
Beà Sílvia, Salaverria Itziar, Armengol Lluís, Pinyol Magda, Fernández Verónica, Hartmann Elena M, Jares Pedro, Amador Virginia, Hernández Luís, Navarro Alba, Ott German, Rosenwald Andreas, Estivill Xavier, Campo Elias
Abstract excerpt
Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. However, only a limited number of target genes have been identified. We have studied 10 MCL cell lines and 28 primary tumors with a combination of a high-density single-nucleotide polymorphism array and gene expression profiling. We detected highly altered genomes...
Topics
- Cell Line, Tumor
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Gene Amplification
- Gene Dosage
- Genes, Neoplasm
- Genome-Wide Association Study
- Homozygote
- Humans