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Article

Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population.

EBioMedicine - 1 Feb 2022

Kang Xiaoying, Jiao Tong, Wang Haiyang, Pernow John, Wirdefeldt Karin

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) is a potent inflammatory cytokine that has been causally associated with coronary artery disease (CAD) and ischemic stroke (IS), implying opportunities for disease prevention by anti-TNF therapeutics. METHODS: Leveraging summary statistics of several genome-wide association studies (GWAS), we assessed the repurposing potential of TNF inhibitors for CAD and IS using...

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Source

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Identifiers

PMID: 35074627
DOI: 10.1016/j.ebiom.2022.103824
PMCID: PMC8792065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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