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From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer

1 Jan 2010

Abstract excerpt

BACKGROUND: Cancer is a complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems, including DNA repair, apoptotic and immune functions. Epigenetic mechanisms, responding to numerous internal and external cues in a dynamic ongoing exchange, play a key role in mediating environmental influences on gene expression and...

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PMID: 20420667
DOI: 10.1186/1475-2867-10-11

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