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Article

Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?

Cancer letters - 1 Nov 2016

Herskind Carsten, Talbot Christopher J, Kerns Sarah L, Veldwijk Marlon R, Rosenstein Barry S, West Catharine M L

Abstract excerpt

Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to tumour cells. Since 80% of individual variation in clinical response is estimated to be caused by patient-related factors, identifying these factors might allow prediction of patients with increased risk of developing severe reactions. While inactivation of cell renewal is considered a major cause of toxicity in...

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Identifiers

PMID: 26944314
DOI: 10.1016/j.canlet.2016.02.035
PMCID: PMC5016239

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