Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it?

doi:10.1093/carcin/23.3.381

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Article

Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it?

Carcinogenesis - 1 Mar 2002

Brennan Paul

Abstract excerpt

One form of defence against cancer development involves a series of genes whose role is to metabolize and excrete potentially toxic compounds and to repair subtle mistakes in DNA. Much laboratory and epidemiological research over the past decade has concentrated on the identification of these genes and an assessment of their role in cancer aetiology. Of particular interest has been whether the risk of cancer...

Topics

DNA Repair
Environment
Genetic Predisposition to Disease
Hazardous Substances
Humans
Neoplasms
Polymorphism, Single Nucleotide
Research Design
Sample Size

Source

Open in PubMed

Identifiers

PMID: 11895852
DOI: 10.1093/carcin/23.3.381

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