Article
Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus.
International immunology - 1 Apr 1999
Eckels D D, Zhou H, Bian T H, Wang H
Abstract excerpt
Numerous investigators have postulated that one mechanism by which hepatitis C virus (HCV) may evade the immune system is through the formation of escape mutants. This hypothesis is based largely on the observed mutability of the viral genome resulting in evolution of diverse quasispecies over the course of infection. That such diversification is a product of viral RNA polymerase infidelity, immune-driven...
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