Article

Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 Months

2021-04-12

Abstract excerpt

<title>Abstract</title> <p>We report orthotopic (life-supporting) survival of genetically engineered porcine cardiac xenografts (with 3-9 progressive gene modifications) for almost 9 months in baboon recipients. This work builds on our previously reported heterotopic cardiac xenograft (3 gene modifications) survival up to 945 days with an anti-CD40 monoclonal antibody-based immunosuppression. In this current stud...

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Literature Corpus work: 14e2607f-7c30-5e1c-b28b-bd3007222589
DOI: 10.21203/rs.3.rs-382870/v1

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Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 MonthsDOI 10.21203/rs.3.rs-382870/v1Read

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