Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody.

doi:10.1097/00007890-199704270-00010

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Article

Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody.

Transplantation - 27 Apr 1997

Orosz C G, Wakely E, Sedmak D D, Bergese S D, VanBuskirk A M

Abstract excerpt

We have treated DBA/2-->C57BL/6 murine cardiac allograft recipients with anti-CD4 monoclonal antibody or with gallium nitrate to promote long-term (>60 days) allograft survival. Within this period, all grafts developed histologic evidence of ongoing vascular and parenchymal tissue remodeling, including interstitial fibrosis and neointimal hyperplasia, which are characteristic of chronic allograft rejection. To...

Topics

Animals
Antibodies, Monoclonal
Autoimmunity
CD4 Antigens
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Count
Cytokines
Female
Gallium
Graft Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heart Transplantation

Immunosuppressive Agents

Isoantibodies

Macrophages

Mice

Mice, Inbred BALB C

Mice, Inbred C3H

Source

Open in PubMed

Identifiers

PMID: 9133472
DOI: 10.1097/00007890-199704270-00010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody.PMID 9133472Read ↗

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