Article
Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study.
Osteoarthritis and cartilage - 1 Jul 2010
Riancho J A, García-Ibarbia C, Gravani A, Raine E V A, Rodríguez-Fontenla C, Soto-Hermida A, Rego-Perez I, Dodd A W, Gómez-Reino J J, Zarrabeitia M T, Garcés C M, Carr A, Blanco F, González A, Loughlin J
Abstract excerpt
OBJECTIVE: Several lines of evidence suggest that estrogens influence the development of osteoarthritis (OA). The aim of this study was to explore the association of two common polymorphisms within the aromatase (CYP19A1) and estrogen receptor (ER) alpha (ESR1) genes with severe OA of the lower limbs. METHODS: The rs1062033 (CYP19A1) and rs2234693 (ESR1) single nucleotide polymorphisms were genotyped in 5528...
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