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Association of repeat polymorphisms in the estrogen receptors α, β, and androgen receptor genes with knee osteoarthritis

11 Aug 2005

Abstract excerpt

Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). To elucidate the possible role of genetic variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta) and androgen receptor (AR) genes with knee OA, the -1174(TA)(n), c.1092+3607(CA)(n), and c.172(CAG)(n) repeat polymorphisms of ER-alpha, ER-beta, and AR genes were studied. A case-control cohort of 158...

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PMID: 16098017
DOI: 10.1111/j.1399-0004.2005.00495.x

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