Article
Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis.
BMC medical genetics - 16 Nov 2010
Kerkhof Hanneke J M, Meulenbelt Ingrid, Carr Andrew, Gonzalez Antonio, Hart Deborah, Hofman Albert, Kloppenburg Margreet, Lane Nancy E, Loughlin John, Nevitt Michael C, Pols Huibert A P, Rivadeneira Fernando, Slagboom Eline P, Spector Tim D, Stolk Lisette, Tsezou Aspasia, Uitterlinden André G, Valdes Ana M, van Meurs Joyce B J
Abstract excerpt
BACKGROUND: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. METHODS: In the discovery study, the Rotterdam Study-I, 7 single nucleotide polymorphisms (SNPs) were genotyped and tested for association with hip (284 cases, 2772 controls), knee (665 cases, 2075 controls), and hand OA (874 cases, 2184 controls) using an additive model....
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