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Article

Genetic polymorphism of the estrogen receptor alpha gene and susceptibility to osteoarthritis: evidence based on 15,022 subjects.

Current medical research and opinion - 1 Jun 2015

Wang Qi, Yan Xiao-Bin, Sun Qian-Qian, Hu Ai-Min, Liu Hong-Li, Yin Yan-Wei

Abstract excerpt

OBJECTIVE: Several lines of evidence suggest that estrogen receptor alpha (ER-α) gene polymorphism may influence the development of osteoarthritis (OA). However, the results are inconsistent. The aim of this study was to explore using a meta-analysis whether rs2234693 (ER-α PvuII T/C) polymorphism confers significant susceptibility to OA. METHODS AND RESULTS: A systematic search of all relevant studies published...

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Identifiers

PMID: 25892216
DOI: 10.1185/03007995.2015.1037727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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