Article
The single nucleotide polymorphism (SNP) of the estrogen receptor-β gene, rs1256049, is associated with knee osteoarthritis in Korean population.
The Knee - 1 Jan 2014
Lee Suk Woo, Song Joo Hyoun, Choi Won Suk, Yoon Jung Hwan, Kim Olga, Park Yong Gyu, Nam Suk Woo, Lee Jung Young, Park Won Sang
Abstract excerpt
BACKGROUND: Estrogens affect articular cartilage metabolism via estrogen receptors (ER) in chondrocytes and are believed to play an important role in the pathophysiology of osteoarthritis (OA). The aim of this study is to determine whether the single nucleotide polymorphism (SNP) of the estrogen receptor-β (ER-β) is associated with an increased susceptibility to knee OA. METHODS: The possible influence of the SNP...
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