Article
Consequences of compromised mitochondrial genome integrity.
DNA repair - 1 Sept 2020
Gustafson Margaret A, Sullivan Eric D, Copeland William C
Abstract excerpt
Maintenance and replication of the mitochondrial genome (mtDNA) is essential to mitochondrial function and eukaryotic energy production through the electron transport chain. mtDNA is replicated by a core set of proteins: Pol γ, Twinkle, and the single-stranded DNA binding protein. Fewer pathways exist for repair of mtDNA than nuclear DNA, and unrepaired damage to mtDNA may accumulate and lead to dysfunctional...
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