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Article

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

Neuroscience - 11 Aug 2010

Jenner A M, Lim W L F, Ng M P E, Wenk M R, Shui G, Sharman M J, Gandy S E, Martins R N

Abstract excerpt

Despite apolipoprotein E's important role in cholesterol transport and metabolism in the brain as well as its influence on Alzheimer's disease, the impact of the human APOE genotype on cholesterol metabolism in brain has not been fully examined. This study was carried out to investigate APOE genotype effects on oxysterols measured. In this study the measurement of cholesterol and several oxysterols in the brains...

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Source

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Identifiers

PMID: 20416362
DOI: 10.1016/j.neuroscience.2010.04.026
PMCID: PMC3991300

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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