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Article

APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Sharman Matthew J, Morici Michael, Hone Eugene, Berger Tamar, Taddei Kevin, Martins Ian J, Lim Wei Ling F, Singh Sajla, Wenk Markus R, Ghiso Jorge, Buxbaum Joseph D, Gandy Sam, Martins Ralph N

Abstract excerpt

The epsilon4 allele of apolipoprotein E (APOE) is currently the major genetic risk factor identified for Alzheimer's disease (AD). Previous in vivo data from our laboratory has demonstrated that amyloid-beta (Abeta) is rapidly removed from the plasma by the liver and kidney and that the rate of i...

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Source

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Identifiers

PMID: 20555142
DOI: 10.3233/JAD-2010-100141
PMCID: PMC3292909

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20555142-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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