Article
Association between an ASIC3 gene variant and insulin resistance in Taiwanese.
Clinica chimica acta; international journal of clinical chemistry - 5 Aug 2010
Wu Semon, Hsu Lung-An, Chou Hsin-Hua, Teng Ming-Sheng, Chang Hsien-Hsun, Yeh Kuan Hung, Chen Chih-Cheng, Chang Pi-Yueh, Cheng Ching-Feng, Ko Yu-Lin
Abstract excerpt
BACKGROUND: Acid-sensing ion channel 3 (ASIC3) is a ligand-gated cation channel activated by extracellular protons. ASIC3(-/-) mice exhibit protection against age-dependent glucose intolerance with enhanced insulin sensitivity. METHODS: To determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were...
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