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Article

Joint effect of hypertension and APOE genotype on CSF biomarkers for Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Kester Maartje I, van der Flier Wiesje M, Mandic Gorana, Blankenstein Marinus A, Scheltens Philip, Muller Majon

Abstract excerpt

We examined the impact of hypertension on cerebrospinal fluid (CSF) biomarkers amyloid-beta1-42 (Abeta42), total tau (tau), and phosphorylated tau at threonine 181 (ptau-181), and assessed the modifying role of APOE genotype in this relation in 546 patients (mean age 65 +/- 10, 47% female) from our memory-clinic. Of these patients 150 had subjective complaints, 140 were diagnosed with mild cognitive impairment,...

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Source

Identifiers

PMID: 20413898
DOI: 10.3233/JAD-2010-091198

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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