A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease.

doi:10.1093/hmg/dds492

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Article

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease.

Human molecular genetics - 1 Mar 2013

Holmans Peter, Moskvina Valentina, Jones Lesley, Sharma Manu, Vedernikov Alexey, Buchel Finja, Saad Mohamad, Sadd Mohamad, Bras Jose M, Bettella Francesco, Nicolaou Nayia, Simón-Sánchez Javier, Mittag Florian, Gibbs J Raphael, Schulte Claudia, Durr Alexandra, Guerreiro Rita, Hernandez Dena, Brice Alexis, Stefánsson Hreinn, Majamaa Kari, Gasser Thomas, Heutink Peter, Wood Nicholas W, Martinez Maria, Singleton Andrew B, Nalls Michael A, Hardy John, Morris Huw R, Williams Nigel M

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting 1-2% in people >60 and 3-4% in people >80. Genome-wide association (GWA) studies have now implicated significant evidence for association in at least 18 genomic regions. We have studied a large PD-meta analysis and identified a significant excess of SNPs (P < 1 × 10(-16)) that are associated with PD but fall short of the...

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PMID: 23223016
DOI: 10.1093/hmg/dds492
PMCID: PMC3561909

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