Article
Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.
British journal of pharmacology - 1 May 2010
Chisari M, Shu H-J, Taylor A, Steinbach J H, Zorumski C F, Mennerick Steven
Abstract excerpt
BACKGROUND AND PURPOSE: Some neurosteroids, notably 3alpha-hydroxysteroids, positively modulate GABA(A) receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulate GABA receptors. We examined whether there was similarity among the actions of these agents and the mechanisms of neurosteroids. Significant similarity would...
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