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Article

Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.

British journal of pharmacology - 1 Aug 2022

Kysilov Bohdan, Hrcka Krausova Barbora, Vyklicky Vojtech, Smejkalova Tereza, Korinek Miloslav, Horak Martin, Chodounska Hana, Kudova Eva, Cerny Jiri, Vyklicky Ladislav

Abstract excerpt

BACKGROUND AND PURPOSE: N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic plasticity, and mutations in human genes encoding NMDAR subunits have been described in individuals with various neuropsychiatric disorders. Compounds with a positive allosteric effect are thought to compensate for reduced receptor function. EXPERIMENTAL APPROACH: We have used whole-cell patch-clamp electrophysiology...

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PMID: 35318645
DOI: 10.1111/bph.15841

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