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Article

Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.

British journal of pharmacology - 1 Nov 2009

Li Ping, Bandyopadhyaya Achintya K, Covey Douglas F, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

BACKGROUND AND PURPOSE: Potentiating neurosteroids are some of the most efficacious modulators of the mammalian GABA(A) receptor. One of the crucial interactions may be between the C20 ketone group (D-ring substituent at C17) of the neurosteroid, and the N407 and Y410 residues in the M4 domain of the receptor. In this study, we examined the contribution of hydrogen bonding between 17beta-substituents on the...

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Identifiers

PMID: 19702782
DOI: 10.1111/j.1476-5381.2009.00390.x
PMCID: PMC2782341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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