Article
Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.
Scientific reports - 18 Jun 2015
Vyklicky Vojtech, Krausova Barbora, Cerny Jiri, Balik Ales, Zapotocky Martin, Novotny Marian, Lichnerova Katarina, Smejkalova Tereza, Kaniakova Martina, Korinek Miloslav, Petrovic Milos, Kacer Petr, Horak Martin, Chodounska Hana, Vyklicky Ladislav
Abstract excerpt
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate. Here, we identify the molecular basis of the use-dependent and voltage-independent inhibitory effect of neurosteroids on NMDAR responses. The site of action is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.