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Article

Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.

Molecular pharmacology - 1 Apr 2009

Bracamontes John R, Steinbach Joe Henry

Abstract excerpt

Neuroactive steroids are efficacious potentiators of GABA-A receptors. Recent work has identified a site in the alpha1 subunit of the GABA-A receptor, that is essential for potentiation by steroids. However, each receptor contains two copies of the alpha1 subunit. We generated concatemers of subunits so that the alpha1 subunits could be mutated separately and examined the consequences of mutations that remove...

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Identifiers

PMID: 19176850
DOI: 10.1124/mol.108.053629
PMCID: PMC2684936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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